Pretreated lham graft covering for retinal detachment with posterior retinal breaks above chorioretinal atrophy in pathologic myopia.

PURPOSE:To compare the surgical results of vitrectomy with untreated or pretreated lyophilized human amniotic membrane (LhAM) grafts covering in treating retinal detachment (RD) related to posterior retinal breaks above chorioretinal atrophy (CRA) in pathologic myopia (PM). METHODS:Nineteen patients with RD related to macular hole (MH) located above macular atrophy (MA) and/or posterior paravascular retinal breaks (PRBs) located above patchy CRA in PM were included. These eyes underwent vitrectomy with untreated LhAM covering (n = 10) or perfluorocarbon liquid (PFCL)-assisted pretreated LhAM covering (n = 9; grafts were pretreated in 0.125% indocyanine green and 50% hypertonic glucose solution for 15 to 20 minutes). The closure of the MH or PRBs, reattachment of the retina and best corrected visual acuity (BCVA) were measured postoperatively. RESULTS:Postoperatively, graft dislocation or shift was only found in 2 eyes (20%) in the untreated group. The closure rate of the MH or PRBs was 80% (8/10) and 100% (9/9) in the untreated group and pretreated group, respectively. The occurrence rate of excessive gliosis was 40% and 11% in the untreated group and the pretreated group, respectively. In both groups. BCVA was improved and the retinal reattachment rate was 100% at the final visit. CONCLUSIONS:PFCL-assisted pretreated LhAM graft covering was effective in treating RD related to MH and/or PRBs situated above MA or patchy CRA in PM. This technique appeared to reduce graft dislocation or shift, promote the closures of MHs/PRBs, and reduce the occurrence of gliosis.