Circulating mirnas in a low-volume disease murine model of mutated high-grade serous ovarian cancer

Allison Gockley,Stephen Fiascone,Kathleen T Hasselblatt,Wojciech Fendler,Ross S. Berkowitz,Kevin M. Elias

Gynecologic Oncology（2019）

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摘要

Objective: The primary objective of this study was to validate a serum microRNA (miRNA) signature and the kinetics of miRNA expression in a murine xenograft model of human BRCA-mutated high-grade serous ovarian cancer (HGSOC). The secondary objective was to relate miRNA expression to volume of disease.

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mirnas,cancer,low-volume,high-grade

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