An Automated Detection of Amyotrophic Lateral Sclerosis from Resting-State MEG Data Using 3D Deep Convolutional Neural Network.

A novel 3D deep convolutional neural network (3D-CNN) model called MEGNet3D has been proposed in the paper. MEGNet3D is designed to differentiate between amyotrophic lateral sclerosis (ALS) and healthy individuals from their resting state (eyes open and eyes closed condition) sensor-level magnetoencephalography (MEG) data. The raw MEG data is initially transformed into their time-frequency representation, which are then used as inputs to MEGNet3D. Both magnetometer and gradiometer recordings have been investigated separately. The proposed model exhibits an accuracy of over 75% for most classification conditions. Thus, MEGNet3D is capable of handling high subject variability and shows that spectral-temporal representation of resting-state MEG data yields relevant neural markers related to the existence of ALS. Furthermore, it has also been observed resting state with eyes closed yields better classification accuracy as compared to the resting state with eyes open condition.