Ni-Catalyzed/mediated C-X (X=N, O, S) Bond Formation Chelation-Assisted by Bidentate Directing Groups

Recently, transition-metal-catalyzed C-H functionalization has attracted significant attention due to its potential applications in different fields. Among different metals, nickel is regarded as a more sustainable 3d-transition metal, which has been widely explored. Therefore, this review focuses on the recent advances in the field of nickel-catalyzed C-H functionalization assisted with bidentate directing groups (DGs) to construct C-X (N, S, O) bond. The latest advancement in nickel catalysed C-X (N, S, O) bond are reviewed and covers literatures from 2015-2022. In addition, the substrate scope and limitations as well as partial mechanism are discussed. Transition metal-catalyzed C-H functionalization strategy has been widely verified as one of feasible method in organic synthetic chemistry. In th review, nickel-catalyzed/ mediated C-H functionalization reactions are broadly discussed to construct C-X (N, S, O) by various amide-based bidentate directing groups.Compared to other directing groups, amide-based bidentate directing are easier to synthesize and be removed. image