Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization. Part 1: Theoretical Basis and Workflow for Efficient Impurity Rejection

Fredrik L. Nordstrom,Mitchell Paolello, Na Yao,Travis Armiger, Qi Jiang, James Nicholson, Joseph Kratz, Michael Toresco, Alexander Lipp, Swjatoslaw Witte, Manuel Henry,C. Scott Shultz,Eric Sirota,Gerard Capellades

Organic Process Research & Development（2024）

Cited 3|Views3

Key words

crystallization,purification,impurityrejection,impurity purge,solid solution,workflow,pharmaceuticals

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