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Process Development and Manufacture of the Core Starting Material of Adagrasib (MRTX849)

Thomas Scattolin, Dinesh Jagannath Paymode,David Robinson Snead,Zhichao Lu, Stanley Yu, Maxime Robert-Monpate, Maria Noelia Chao, Thomas Michael Haas, Hanhui Wang, Xuewei Liang,Cheng-yi Chen

Organic Process Research & Development（2024）

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关键词
MRTX849,KRAS(G12C),adagrasib,beta-ketoester,oncology,Dieckmann condensation
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