Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer’s disease model by restoring BDNF signaling

Wanbing Wang,Yanzhong Li,Fangling Ma,Xuan Sheng,Kai Chen,Rengong Zhuo,Chen Wang,Honghua Zheng,Yun-wu Zhang,Guojun Bu,Xiao-Fen Chen,Li Zhong

Brain, Behavior, and Immunity（2023）

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摘要

•Microglial repopulation attenuates AD-associated cognitive deficits.•Repopulating microglia enhance hippocampal LTP and synaptic proteins.•Repopulating microglia recover cell morphology and synaptic engulfment.•Microglial repopulation restores neurotrophic signaling and hippocampal neurogenesis.•Repopulation elevates BDNF expression from microglia, boosting synaptic plasticity.

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关键词

Alzheimer's disease,5xFAD,Microglia,PLX3397,Repopulation,BDNF,Neurotrophic signaling pathway

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