(‒)-Epicatechin reveals amoebicidal activity against Acanthamoeba castellanii by activating the programmed cell death pathway

Hương Giang Lê,Jung-Mi Kang,Tuấn Cường Võ,Won Gi Yoo,Yeonchul Hong,Byoung-Kuk Na

Phytomedicine（2024）

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摘要

•(‒)-Epicatechin revealed amoebicidal activity against Acanthamoeba trophozoites without cytotoxicity to mammalian cells•(‒)-Epicatechin induced death of Acanthamoeba castellanii via apoptosis-like programmed cell death and autophagic cell death pathways•(‒)-Epicatechin could be a candidate drug or supplemental compound for treating Acanthamoeba infections

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Acanthamoeba,(‒)-Epicatechin,amoebicidal activity,cysticidal activity,programmed cell death

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