Stereotactic Body Radiotherapy for Pancreatic Cancer - A Systematic Review of Prospective Data

Mohamed A Shouman,Frederik Fuchs,Franziska Walter,Stefanie Corradini,C Benedikt Westphalen,Marlies Vornhülz,Georg Beyer, Dorian Andrade,Claus Belka,Maximilian Niyazi,Paul Rogowski

Clinical and Translational Radiation Oncology（2024）

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摘要

•Review of 31 prospective SBRT studies for PDAC including 1,571 patients in various clinical scenarios.•LAPC: SBRT in LAPC shows favorable local control, potential for resection (up to 39%).•BRPC: SBRT plus modern systemic therapies achieve high resection rates (up to 80%).•MRgRT offers potential for optimal dosing with fewer side effects.•Urgent need for broader randomized trials with well-defined patient cohorts to further clarify SBRT's role in PDAC.

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BED,BED10,BRPC,CRT,FFLP,ILR,LAPC,LC,MRgRT,mPDAC,NRS,OAR,OS,PDAC,PFS,PRISMA,R0,RPC,SBRT,SIB,SIP,SMART,PRV

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