Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia

Lauren Edwards,Kelsey R. Thomas,Alexandra J. Weigand,Emily C. Edmonds,Alexandra L. Clark,Einat K. Brenner,Sarah J. Banks,Paul E. Gilbert,Daniel A. Nation,Lisa Delano-Wood,Mark W. Bondi,Katherine J. Bangen

Cerebral Circulation - Cognition and Behavior（2024）

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摘要

•Early cerebrovascular dysfunction has been observed in Alzheimer's disease•Pulse pressure and APOE ε4 dose interacted to affect cerebral blood flow•Higher pulse pressure was related to lower cerebral blood flow in ε4/ε4 individuals•Vascular risk management is crucial particularly for those with genetic risk for AD

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Alzheimer's disease,apolipoprotein E,arterial spin labeling,cerebral blood flow,pulse pressure

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