Model-Based Learn and Confirm: Designing Effective Treatment Regimens Against Multidrug Resistant Gram-negative Pathogens

Estefany Garcia,John K. Diep,Rajnikant Sharma,Gauri G. Rao

International journal of antimicrobial agents（2024）

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摘要

•An antibiotic resistance research framework advocating the use of PK/PD approaches•Leveraging low-cost, high-yield preclinical studies for model-informed drug optimization•Combination therapy against PMB-susceptible and PMB-resistant CRKP isolates

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关键词

Polymyxins,pharmacokinetics,pharmacodynamics,PK,PD,model-based,time-kill studies,in vitro dynamic infection model

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