Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity

Maria F. Fernandes,Juan J. Aristizabal-Henao, Phillip M. Marvyn, Iman M’Hiri, Meghan A. Wiens,Monica Hoang,Manuel Sebastian,Renato Nachbar,Philippe St-Pierre, Kalsha Diaguarachchige DeSilva,Geoffrey A. Wood,Jamie W. Joseph,Christine A. Doucette,André Marette,Ken D. Stark,Robin E. Duncan

Molecular Metabolism（2024）

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摘要

•Renal-tubule cell triacylglycerol accumulation does not alone cause lipotoxicity•Renal adipose triglyceride lipase (ATGL) loss increases diacylglycerol kinase-ε•Renal ATGL loss increases kidney and blood lysophosphatidic acid levels•Endogenous lysophosphatidic acid (LPA) impairs GLP-1 secretion•LPA can mediate kidney-gut-pancreas cross-talk to impair glucose homeostasis

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关键词

adipose triglyceride lipase (ATGL),renal tubule cells,lysophosphatidic acid,glucagon-like peptide 1,glucose-stimulated insulin secretion,diabetes

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