Phase Separation of Chimeric Antigen Receptor Promotes Immunological Synapse Maturation and Persistent Cytotoxicity

Xinyi Xu, Haotian Chen, Zhengxu Ren, Xiaomin Xu,Wei Wu,Haochen Yang, Jinjiao Wang, Yumeng Zhang, Qiuping Zhou,Hua Li, Shaoqing Zhang,Haopeng Wang,Chenqi Xu

IMMUNITY（2024）

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chimeric antigen receptor,phase separation,immunological synapse,CD2 costimulation,antigen sensitivity,persistence,CAR-T cell therapy,exhaustion,trogocytosis,tonic signaling

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