Expression of stem cell markers as predictors of therapeutic response in metastatic prostate cancer patients

•The potential role of targeting Cancer stem cells (CSCs) as a prognostic marker and therapeutic strategy in the treatment of metastatic prostate cancer.•Promising avenue for a more comprehensive and effective approach to managing metastatic prostate cancer (PCA), paving the way for further exploration and therapeutic advancements in PCA treatment.•Potential therapeutic efficacy of targeting CSCs and also emphasize the significance of CSCs as prognostic and predictive markers in the context of metastatic PCA.