JiaGaSongTang improves chronic cholestasis via enhancing FXR-mediated bile acid metabolism

Xiaoliang He, Yingya Zhou, Jingtao Yu, Qinpo Huang,Zhengyuan Chen, Ru Xiao,Changhui Liu,Shuhua Gui,Tianqin Xiong

Phytomedicine（2024）

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摘要

•Subcutaneous injection induced chronic cholestasis enhances understanding of BA in gut-liver axis.•6-gingerol binds to and active FXR to trigger transcription of downstream BA genes.•JGST and 6-gingerol reverse chronic cholestasis via FXR in treating various enterohepatic issues.

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关键词

JiaGaSongTang,6-gingerol,chronic cholestasis,bile acid,farnesoid X receptor

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