High linoleic acid levels in red blood cells predict a poor response to neoadjuvant chemotherapy in HER2-positive breast cancer patients

Rodrigo Valenzuela,Benjamín Walbaum,Camila Farias,Francisco Acevedo, Catalina Vargas, José Tomas Bennett, M. Loreto Bravo, Mauricio P. Pinto,Lidia Medina,Tomas Merino,Carolina Ibañez, Alejandra Parada,Cesar Sanchez

Nutrition（2024）

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摘要

•Red-blood cell membrane fatty acid levels are associated with chemotherapy response.•Higher omega-6 fatty acids are associated with poorer response to chemotherapy.•Multivariate analysis confirm only linoleic acid was associated with poorer response.•Red-blood cell membrane linoleic acid could serve as a predictor of poorer response.

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关键词

Breast neoplasm,chemotherapy,biomarkers. fatty acids,polyunsaturated fatty acids,omega-3,omega-6

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