Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis

Jun Zhao,Yan Liu,Xiaoyi Shi,Junlong Dang,Yu Liu,Siwen Li,Wei Cai,Yuluan Hou,Donglan Zeng,Ye Chen,Jia Yuan,Yiding Xiong,Wenbin Wu,Peihong Cai,Jingrong Chen,Jianbo Sun, Yiming Shao,David D. Brand,Song Guo Zheng

Journal of Advanced Research（2023）

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摘要

•K/B × N arthritis model-derived sera and synovial fluid can stimulate NETs formation.•GMSCs inhibit both peripheral and synovial NETs formation by secreting manner.•GMSCs suppress NETs formation via PGE2-PKA-ERK signaling pathway.•GMSCs ameliorate arthritis by suppressing NETs formation.

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关键词

Rheumatoid arthritis,Gingival-derived mesenchymal stem cells,Neutrophil extracellular traps,PGE2-PKA-ERK axis

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