Effects of lifestyle and associated diseases on serum CC16 suggest complex interactions among metabolism, heart and lungs

Nathalie Rohmann,Paula Stürmer,Corinna Geisler,Kristina Schlicht,Carina Knappe, Katharina Hartmann,Kathrin Türk,Tim Hollstein,Alexia Beckmann,Anna K. Seoudy,Ulla Becker,Perdita Wietzke-Braun,Ute Settgast,Florian Tran,Philip Rosenstiel,Jan H. Beckmann,Witigo von Schönfels,Stephan Seifert,Jan Heyckendorf,Andre Franke

Journal of Advanced Research（2023）

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摘要

•CC16 is an anti-inflammatory, immunomodulatory protein expressed in respiratory club cells.•Severe abdominal obesity and arterial hypertension robustly decrease serum CC16.•ACEi/ARBs, uricosurics and chronic heart failure robustly increase serum CC16.•Effects might be mediated by adipose tissue inflammation as well as RAAS and uric acid disturbance.•Findings indicate a complex interplay of the metabolic, respiratory and cardiovascular system.

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