Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells

Marten A. Fischer,Al-Hassan M. Mustafa,Kristin Hausmann,Ramy Ashry,Anita G. Kansy,Magdalena C. Liebl,Christina Brachetti,Andrea Piée-Staffa,Matthes Zessin,Hany S. Ibrahim,Thomas G. Hofmann,Mike Schutkowski,Wolfgang Sippl,Oliver H. Krämer

Journal of Advanced Research（2023）

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摘要

•Novel HDACi with nanomolar activity against leukemic cells were synthesized.•HDACi of the KH-series are superior to a clinical grade HDACi.•HDACi of the KH-series modulate acetylation and phosphorylation of proteins.•The new HDACi KH16 regulates cell cycle arrest, apoptosis, and autophagy.•Apoptosis acts upstream of autophagy in KH16-treated cells.

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关键词

Acetylation,Apoptosis,Autophagy,HDAC,HDACi,Isoenzyme specificity

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