Enteric fungi protect against intestinal ischemia–reperfusion injury via inhibiting the SAA1-GSDMD pathway

Yihui Chen,Ben Han,Xu Guan,Guangsheng Du,Baifa Sheng,Xiaoqi Tang,Quanchao Zhang,Huichao Xie,Xianhong Jiang,Qianshan Tan,Shuaishuai Chen,Jian Wang,Wei Chen,Weidong Xiao

Journal of Advanced Research（2023）

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摘要

•Enteric fungi diversity was markedly altered in IIR injury.•Fungal colonization or mannan could alleviate IIR injury by decreasing GSDMD-mediated pyroptosis of IECs.•The protective role of fungi in IIR injury depends on macrophage involvement.•Single-fungal strains and mannan both alleviate GSDMD cleavage induced by reducing SAA1 expression of macrophages.

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关键词

Enteric fungi,Intestinal ischemia–reperfusion injury,Mannan,Antifungal therapy,Pyroptosis

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