Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol

Anna Bertolini,Vincent W. Bloks,Marijn Wilmink,Eline Bos,Ivo P. van de Peppel,Roos Eilers,Sake Prins,Rachel Thomas,Alain de Bruin,Henkjan Verkade,Johan W. Jonker

Journal of Cystic Fibrosis（2023）

引用 0|浏览3

暂无评分

摘要

•Cystic fibrosis (CF) features bile acids, fat, and cholesterol malabsorption.•Malabsorption is associated with decreased intestinal nuclear receptor signaling.•The laxative PEG increased bile acids, fat, and cholesterol absorption in CF mice.•Concomitantly, PEG improved intestinal nuclear receptor signaling in CF mice.•PEG decreased hepatic inflammation and cholesterol synthesis in CF mice.

查看译文

关键词

Cystic fibrosis,Malabsorption,Polyethylene glycol,Nuclear receptors,Cholesterol,Bile acids

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要