Solubility measurements and molecular dynamics simulations of perphenazine (form I) in three binary solvent systems

•The solubility of perphenazine (form I) in binary solvent systems were determined.•Experimental solubility data were correlated by different models.•The intermolecular interaction of the perphenazine (form I) was analyzed by HS.•RDF analysis was used to explain the solute-solvent and solvent-solvent interactions.•Thermodynamic properties of the dissolution process were calculated and discussed.