Microbiota modulation by dietary beta-glucan prevents steatotic liver disease progression

Julius W. Jaeger,Annette Brandt,Wenfang Gui,Timur Yergaliyev,Angélica Hernández-Arriaga, Mukil Marutha Muthu,Karolina Edlund, Ahmed Elashy,Antonio Molinaro, Diana Möckel, Jan Sarges, Emina Halibasic,Michael Trauner,Florian Kahles, Ulrike Rolle-Kampczyk,Jan Hengstler,Carolin Victoria Schneider,Twan Lammers,Hanns-Ulrich Marschall, Martin von Bergen

JHEP Reports（2024）

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摘要

•Oat beta-glucan exhibits a strong hepatoprotective effect in MASLD, especially against fibrosis progression.•Supplementation of oat beta-glucan dampens infiltration of monocyte-derived macrophages and the PRR-driven innate immune response.•Oat beta-glucan reshapes intestinal microbiota composition by promoting protective bacterial taxa to reduce translocation of TLR4 ligands.•Bile acid composition remains largely unaffected by beta-glucan supplementation.

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关键词

MASLD,beta-glucan,microbiota,fibrosis,gut-liver axis,prebiotics

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