Dynamic evolution of the sofosbuvir-associated variant A1343V in HEV-infected patients under concomitant sofosbuvir-ribavirin treatment

André Gömer,Katja Dinkelborg,Mara Klöhn,Michelle Jagst,Michael Hermann Wißing,Nicola Frericks, Pia Nörenberg,Patrick Behrendt,Markus Cornberg,Heiner Wedemeyer,Eike Steinmann, Benjamin Maasoumy,Daniel Todt

JHEP Reports（2024）

引用 0|浏览2

暂无评分

摘要

•Sofosbuvir and Ribavirin combination therapy efficiently decreased viral RNA in blood and stool in patients with chronic HEV infection.•Variants that are associated with antiviral resistance emerged during treatment•High dose combination treatment is efficient in repressing viral replication of single and multi-variant clones in vitro

查看译文

关键词

Viral RNA-directed RNA polymerase inhibitors,high-throughput sequencing,resistance profiling,intra-host evolution

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要