Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications

•NO-based therapeutics remain a cornerstone of cardiovascular pharmacology, but would benefit from targeted and controlled delivery.•Nanomaterials can function as highly tunable platforms for drug delivery including NO via catalytic and noncatalytic approaches.•Multiple nanomaterials have been investigated for NO delivery in vascular stents and grafts, reperfusion injury, and tissue engineering.•Clinical translation will require multidisciplinary cooperation to optimize material properties, address safety concerns, and test in large animal models.