Amount of Gleason Pattern 3 Is Not Predictive of Risk in Grade Group 2–4 Prostate Cancer

We investigated whether total Gleason pattern 3 or the proportion of Gleason pattern 4 on biopsy is a significant predictor of adverse pathology. Our findings suggest that quantifying the amount rather than the proportion of Gleason pattern 4 would improve grade group assignment for decision-making in localized prostate cancer.