Synthesis of P-Stereogenic Compounds by Transition Metal-Catalyzed Asymmetric Transformation of H-P(O) Compounds: Progress, Challenges, and Prospects

The synthesis of P-stereogenic phosphorus compounds has gained considerable attention due to their wide applications across many research fields. Among the available strategies, transition metal-catalyzed asymmetric transformation of pentavalent phosphoryl (H-P(O)) precursors is particularly appealing. This approach involves a direct C-P bond-forming process, rendering it straightforward, and it employs readily available, bench-stable H-P(O) reagents that are compatible with various metal catalysts. Recent years have witnessed significant progress in this field, with a primary focus on asymmetric C-P cross-couplings and hydrophosphorylations. This Concept article provides a brief summary of recent progress, highlights existing challenges, and discusses future directions in this exciting area. The synthesis of P-stereogenic phosphorus compounds has gained significant attention due to their broad utility in various research areas. In this Concept, we reviewed the burgeoning transition metal-catalyzed asymmetric transformations involving pentavalent phosphoryl precursors. Emphasizing direct C-P bond formation, we illuminate recent advances, challenges, and forthcoming avenues, offering a succinct yet comprehensive exploration of this vibrant research field.image