Immunoglobulin replacement vs prophylactic antibiotics for hypogammaglobulinemia secondary to haematological malignancy

Zoe K. McQuilten,Robert Weinkove,Le Thi Phuong Thao,Philip Crispin, Amber Degelia,Claire Dendle,Michael Gilbertson,Anna Johnston,Anastazia Keegan,Dominic Pepperell,Humphrey Pullon,John Reynolds, Tina van Tonder,Judith Trotman,Neil Waters,Cameron Wellard,Helen Weston, C. Orla Morrissey,Erica M. Wood

Blood Advances（2023）

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摘要

•First trial to compare immunoglobulin and prophylactic antibiotics in patients with secondary hypogammaglobulinemia due to blood cancers•A similar proportion of participants remained on antibiotics at twelve months as immunoglobulin, with similar rates of major infection•These results support the feasibility of a phase III trial

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