Venetoclax and Cobimetinib in Relapsed/Refractory AML: A Phase 1b Trial

Clinical Lymphoma Myeloma and Leukemia（2024）

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摘要

•Ven-cobi showed limited efficacy, similar to venetoclax alone, in R/R AML.•Ven-cobi had additional toxicity versus venetoclax alone in patients with R/R AML.•High MCL-1 levels and TP53/signaling mutations may promote ven-cobi resistance.•These findings may optimize future trials of BCL-2/MAPK inhibitor combinations.

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关键词

B-cell lymphoma-2,Biomarker,Mitogen-activated protein kinase pathway,Targeted therapy

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