[ZeoDABCO-SO3H]Cl catalyzed synthesis, cytotoxicity against normal kidney cell line and molecular docking study of dihydropyrimidines-2-ones/thiones

Neelam Deshmukh, Jayavant Deshmukh, Nikhil Deshmukh,Sandeep Sankpal,Shankar Hangirgekar

Journal of Molecular Structure（2024）

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摘要

•Synthesis of [ZeoDABCO-SO3H]-Cl Bronsted acidic heterogeneous catalyst.•The catalyst is utilized for the synthesis of 2,3-dihydropyrimidines-2-ones/ thiones in excellent yields.•The promising cytotoxicity activity against normal kidney cell lines.•An analysis of the human LTA4H protein's molecular docking against leukotriene A4 hydrolase.•Molecular Docking Results of (4a-j) series compounds with epidermal growth factor receptor tyrosine kinase

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关键词

Dihydro pyrimidines-2-ones/ thiones,Molecular docking,[ZeoDABCO-SO3H]Cl,Cytotoxicity,MTT assay

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