Anhydrous Carbene Insertion Reactions: A Synthetic Platform for DNA-Encoded Library

An operationally simple anhydrous carbene insertion reaction to construct DNA-encoded libraries (DEL) is reported. The developed reaction employs visible light photolysis of diazo compounds and Reversible Adsorption to Solid Support (RASS) strategy. From readily available amines, alcohols, phenols, and carboxylic acids, a variety of high-value molecules, including useful unnatural amino acids, ethers, and esters, promising clinical drug derivatives, and bioactive molecules have been constructed. image