Clinical impact of cerebral protection during transcatheter aortic valve implantation
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION(2024)
摘要
Background: Embolization of debris can complicate transcatheter aortic valve implantation (TAVI) causing stroke. Cerebral embolism protection (CEP) devices can divert or trap debris. Purpose: To evaluate the efficacy of CEP during TAVI vs the standard procedure. Data Source: sPubMed, SCOPUS and DOAJ 1/01/2014-04/12/2023. Study Selection: Randomized and observational studies comparing CEP versus standard TAVI, according to PRISMA. Primary outcome: stroke. Secondary outcomes: death, bleeding, vascular access complications, acute kidney injury and infarct area. Data Extraction: Two investigators independently assessed study quality and extracted data. Data Synthesis: Twenty-six articles were included (540.247 patients). The primary endpoint was significantly lower (RR = 0.800 95%CI:0.682-0.940; p = 0.007) with CEP. Similarly, death rates were significantly lower with CEP (RR = 0.610 95%CI:0.482-0.771; p < 0.001). No difference was found for bleeding (RR = 1.053 95%CI:0.793-1.398; p = 0.721), vascular complications (RR = 0.937 95%CI:0.820-1.070; p = 0.334) or AKI (RR = 0.982 95%CI:0.754-1.279; p = 0.891). Conclusions: Use of CEP during TAVI is associated with improved outcomes. Future studies will identify patients who benefit most from CEP.
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关键词
cerebral,debris,embolic,protection,stroke,TAVI
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