Adenosine diphosphate ribosylation factor 6 inhibition protects burn sepsis induced lung injury through preserving vascular integrity and suppressing ASC inflammasome transmission

Mengjing Xiao, Peirong Zhang, Zimiao Chen,Xiaojie Liu,Wei Wei, Zhihao He, Yao Wang, Jian Cheng, Zhen Zhu, Jing Wen, Hongming Yang

Burns（2024）

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摘要

•ARF6 inhibition is effective to preserve vascular integrity in burn sepsis.•ARF6 inhibition restrain both vascular leakage and excessive inflammatory cascade.•Inhibiting ARF6 does not affect the primary inflammatory response in burn sepsis.•ARF6 inhibition could be a promising potential therapeutic to protect against burn sepsis induced lung injury.

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关键词

Burn sepsis,Acute lung injury,Adenosine diphosphate-ribosylation factor 6,ASC inflammasome,Vascular permeability,VE-cadherin

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