Trajectories in county-level Low Birthweight Rates and Associated Contextual Factors in the United States, 2016-2021.

Introduction:Infants with low birthweight (less than 2500 grams) have greater risk of mortality, long-term neurologic disability and chronic diseases such as diabetes and cardiovascular disease as compared to infants with normal birthweight. This study examined the trajectories of low birthweight rate in the U.S. across the metropolitan and non-metropolitan counties over the time period of 2016-2021 and the associated contextual factors. Methods:This longitudinal study utilized data on 21,759,834 singleton births across 3,108 counties. Data on birthweight and maternal sociodemographic and behavioral characteristics was obtained from the National Center for Health Statistics. A generalized estimating equations model was used to examine the association of county-level contextual variables with low birthweight rates. Results:A significant increase in low birthweight rates was observed across the counties over the duration of the study. Large metro and small metro counties had significantly higher low birthweight rates as compared to non-metro counties. High percentage of Black women, underweight women, age more than 35 years, lack of prenatal care, uninsured population, and high violent crime rate was associated with an increase in low-birth-weight rates. Other contextual characteristics (percentage of married women, American Indian/Alaskan Native women, and unemployed population) differed in their associations with low birthweight rates depending on county metropolitan status. Conclusions:Our study findings emphasize the importance of developing interventions to address geographical heterogeneity in low birthweight burden, particularly for metropolitan areas and communities with vulnerable racial/ethnic and socioeconomic groups.