Decreased FGF23 inhibits placental angiogenesis via the ERK1/2-EGR-1 signaling pathway in preeclampsia

Shanshan Zhao, Junling Zhou, Run Chen,Wei Zhou,Huizhen Geng,Yihong Huang, Shaole Shi, Lemin Yuan,Zilian Wang,Dongyu Wang

Cytokine（2024）

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摘要

•Serum FGF23 levels increased with gestational age in normal pregnant women.•Preeclampsia group had lower FGF23 levels than control group in the third trimester.•FGF23 promoted cell migration, invasion and tube formation abilities in vitro.•FGF23 stimulated placental VEGF-A expression via ERK1/2-EGR-1 pathway.•This study provides a potential mechanism involved in progression of preeclampsia.

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关键词

Fibroblast growth factor 23,Preeclampsia,Vascular endothelial growth factor A,Angiogenesis

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