CALR mutation burden in essential thrombocythemia and disease outcome.

Paola Guglielmelli,Natasha Szuber,Naseema Gangat, Giulio Capecchi,Chiara Maccari, Michaël Harnois, Omer Karrar,Maymona Abdelmagid,Manjola Balliu, Elena Nacca,Alessandro Atanasio,Ilaria Sestini, Audrey Désilets,Giuseppe Gaetano Loscocco,Giada Rotunno,Lambert Busque,Ayalew Tefferi,Alessandro Maria Vannucchi

Blood（2024）

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摘要

ABSTRACT:Among 281 patients with essential thrombocythemia and calreticulin (CALR) mutation, we found a variant allele frequency of ≥60% to be associated with significantly shortened myelofibrosis-free survival, mostly apparent with CALR type-1 and CALR type-indeterminate mutations.

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