An LC-MS/MS-based platform for the quantification of multiple amyloid beta peptides in surrogate cerebrospinal fluid

Merve Oztug,Bilgin Vatansever, Gonca Altin,Muslum Akgoz, Suleyman Z. Can

Journal of Mass Spectrometry and Advances in the Clinical Lab(2024)

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摘要
•An LC-MS/MS method was developed to accurately quantify Aβ peptides in CSF.•Uncertainty was evaluated in the method for precise quantification of Aβ peptides.•The PICAA method is utilized in reference material value assignment.
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关键词
,AD,BSA,CRM,CSF,DTT,ELISA,FASP,IAA,ID-MS,ID-LC/MSMS,IFCC,LC/hrMS,LC/MS,LC/MSMS,LOD,LOQ,m/z,MS,NIMJ,PICAA,PRM,QC,RMP,RSD,SI,SIL,SPE,UPLC
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