Activation of ChAT+ neuron in dorsal motor vagus (DMV) increases blood glucose through the regulation of hepatic gene expression in mice

Brain Research(2024)

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摘要
•ChAT+ PNS innervates the liver.•Activation of ChAT+ neurons in DMV brain region increases hepatic ChAT expression.•Increased hepatic ChAT expression results in increased gene expression involving gluconeogenesis and lipogenesis in the liver.•Activation of ChAT+ neurons in DMV brain region increases blood glucose.
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关键词
Designer Receptors Exclusively Activated by Designer Drugs (DREADD),Dorsal MotorVagus nerve (DMV),Parasympathetic Nervous System (PNS),Hepatic metabolic homeostasis
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