Glucagon-like peptide-1 and interleukin-6 interaction in response to physical exercise: An in-silico model in the framework of immunometabolism

Micaela Morettini,Maria Concetta Palumbo, Alessandro Bottiglione, Andrea Danieli, Simone Del Giudice,Laura Burattini,Andrea Tura

Computer Methods and Programs in Biomedicine（2024）

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摘要

•Physical exercise may enhance GLP-1 secretion by interleukin-6 action.•No mathematical model described IL-6-induced GLP-1 secretion due to physical exercise.•We propose a mathematical model of IL-6/GLP-1 interaction following moderate exercise.•We defined the sensitivity of GLP-1 secretion to exercise-mediated IL-6 action.•Model parameters are computable in the single subject, thus have clinical potential.

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关键词

Compartmental model,Parameter estimation,Monte Carlo simulation,Exercise immunometabolism,Inter-organ crosstalk,Myokine

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