Novel Stentless Strategy With Perfusion and Drug-Coated Balloons for Treating Acute Coronary Syndrome

•Stentless treatment of acute coronary syndrome uses gradual, prolonged predilation.•A perfusion balloon combined with a drug-coated balloon was used.•The stentless strategy achieved successful revascularization in most patients.•No acute occlusion or in-hospital major adverse cardiac events were reported.•A low incidence of target vessel failure at 24 months was reported.