Interactions of Body Weight Loss with Lipophilic Toxin Storage: Commentary

A high incidence of obesity and surplus body fat has been observed in wealthy countries for many decades. It is generally recognized thatthese excesses contribute to serious disease states, including type 2 diabetes and cardiovascular diseases. On the other hand, the adiposetissue stores relatively safely many environmental lipophilic toxins. However, rapid weight loss mobilizes these toxins to the blood to beexposed to vital organs, such as the brain, lungs, and others. With the introduction of potent diabetic drugs causing rapid weight reduction,the question of mobilization of lipophilic toxins to the blood should be considered. In this commentary, we raised this mobilization ofadipose tissue toxins to the readers. Also, we discussed how these toxins may be eliminated from the body through the use of nondigestiblefat, such as olestra or lipase inhibitors, such as Xenical.