Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer

•The latest immunotherapeutic strategies for skin cancer are highlighted, with a special focus on tumour-associated macrophages(TAMs).•Interactions between TAMs and immune cells are discussed, underlining the key role of TAMs in shaping the immunosuppressive microenvironment.•The paper comprehensively analyzes the origin, classification, and functions of TAMs, shedding light on their crucial role in skin cancer.•Targeting TAMs as a novel immunotherapy strategy sheds new light on the treatment of skin cancer.•Immunotherapy strategies centred on TAMs could complement existing treatments for skin cancer and show excellent prospects.