Impact of cash transfers on the association between prenatal exposures to high temperatures and low birthweight: Retrospective analysis from the LEAP 1000 study

Objective: To explore the associations between prenatal temperature exposures and low birthweight (LBW) and modification by cash transfer (CT) receipt.Design: Retrospective cohort study.Setting: Five rural districts in Northern Ghana.Population or sample: A total of 3016 infants born to women interviewed as part of the Livelihood Empowerment Against Poverty (LEAP 1000) impact evaluation between 2015 and 2017.Methods: Birthweight was collected using household surveys administered to LEAP 1000 eligible women. We used a UNICEF-developed multiple imputation approach to address missingness of birthweight and applied an empirical heaping correction to the multiply imputed birthweight data. Survey data were linked to the European Centre for Medium -Range Weather Forecasts Reanalysis 5-hourly temperature averaged to weeks for 2011-2017 using community centroids. Using distributed -lag nonlinear models, we explored the lag-specific associations between weekly average temperatures greater than 30 degrees C and LBW, and stratified by LEAP 1000 treatment.Main outcome measures: Low birthweight (<2.5 kg).Results: Twelve percent (n = 365) of infants were LBW; the mean +/- SD birthweight was 3.02 +/- 0.37 kg. Overall, increasing temperatures were associated with increased odds of LBW, with the greatest odds observed in the 3 weeks before birth (odds ratio 1.005-1.025). These positive associations were even larger among comparison infants and null among treatment infants.Conclusions: Our study found increased odds of LBW with high weekly average temperatures throughout pregnancy and the preconception period and demonstrate mitigated effects by the LEAP 1000 CT program. More evidence on the potential of CTs to serve as adaptation interventions in low-and middle-income countries is needed to protect pregnant persons and their infants from the impacts of climate change.