Evaluating an EEG-based tool for assessing acute clinical and cognitive changes in adult outpatients with MDD treated with open-label, flexible-dose vortioxetine: A pilot study

•MDD patients showed increased baseline P200 and P300 latencies compared to healthy controls.•Post-treatment MDD latencies were similar to those of controls, and indicated cognitive changes independent of antidepressant effects.•Automated EEG-based objective assessments can potentially support MDD management and improve outcomes in neuropsychiatric care.