Aberrant GPA expression and regulatory function of red blood cells in sickle cell disease.

Juliana N. Marshall,Matthew N. Klein,Pratap Karki,Kamoltip Promnares,Saini Setua, Xiaoxuan Fan,Paul W. Buehler,Konstantin G. Birukov, Gerardo R. Vasta,Magali J. Fontaine

Blood advances（2024）

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摘要

•RBC transfusion can restore quiescence in previously activated immune cells under inflammatory conditions, such as sickle cell disease.•RBCs restore quiescence of activated leukocytes through their cell surface glycophorin A.

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