Novel Operation Mechanism and Multifunctional Applications of Bubble Microrobots

Microrobots have emerged as powerful tools for manipulating particles, cells, and assembling biological tissue structures at the microscale. However, achieving precise and flexible operation of arbitrary-shaped microstructures in 3D space remains a challenge. In this study, three novel operation methods based on bubble microrobots are proposed to enable delicate and multifunctional manipulation of various microstructures. These methods include 3D turnover, fixed-point rotation, and 3D ejection. By harnessing the combined principles of the effect of the heat flow field and surface tension of an optothermally generated bubble, the bubble microrobot can perform tasks such as flipping an SIA humanoid structure, rotating a bird-like structure, and launching a hollow rocket-like structure. The proposed multi-mode operation of bubble microrobots enables diverse attitude adjustments of microstructures with different sizes and shapes in both 2D and 3D spaces. As a demonstration, a biological microenvironment of brain glioblastoma is constructed by the bubble microrobot. The simplicity, versatility, and flexibility of this proposed method hold great promise for applications in micromanipulation, assembly, and tissue engineering. Microrobots capable of manipulation and assembly is an exciting technology in engineering and medical fields. This study proposes three methods including 3D turnover, fixed-point rotation, and 3D ejection to realize the delicate multifunctional operation of various microstructures based on bubble microrobots. The optothermal bubble microrobot demonstrates its application capabilities by constructing a biological microenvironment of brain glioblastoma in vitro.image