The Relationship between Dietary Macronutrient Composition and Telomere Length Among US Adults

The role of dietary macronutrients and energy intake in the aging process has been well-established. However, previous research has mainly focused on the association between leukocyte telomere length (LTL) and individual macronutrients, while the effects of macronutrient composition on LTL remain unclear. This cross-sectional analysis involved 4130 US adults (44.8 +/- 17.0 years; 51% female) from the National Health and Nutrition Examination Survey during 1999-2002. A single 24-h dietary recall is used to collect dietary data. The relationship between dietary macronutrient composition and LTL wasexamined using three-dimensional generalized additive models. After adjustment for age, sex, ethnicity, education, physical activity, BMI, and dietary quality, a three-dimensional association of macronutrient composition with LTL (P = 0.02) is revealed. Diets lower in protein (5-10%), higher in carbohydrates (75%), and lower in fat (15-20%) are associated with the longest LTL corresponding to 7.7 years of slower biological aging. Diets lowest in protein (5%) and carbohydrate (40%), while highest in dietary fat (55%) are associated with the shortest LTL, corresponding to accelerated biological aging of 4.4 years. The associations appeared magnified with higher energy intake. These findings support a complex relationship between dietary macronutrients and biological aging independent of diet quality. This study of 4130 US adults linked dietary macronutrient intake to leukocyte telomere length (LTL) while controlling for diet quality. Lower protein (5-10%), higher carbohydrate (75%), and lower fat (15-20%) diets correlated with longer LTL, indicative of 7.7 years slower biological aging. Conversely, diets comprised of lower protein (5%), moderate carbohydrate (40%), and higher fat (55%) showed accelerated aging by 4.4 years.image