The preferential effect of Clemastine on F3/Contactin-1/Notch-1 compared to Jagged-1/Notch-1 justifies its remyelinating effect in an experimental model of multiple sclerosis in rats

Sherehan M. Ibrahim,Ahmed S. Kamel,Kawkab A. Ahmed,Reham A. Mohammed,Reham M. Essam

International Immunopharmacology（2024）

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摘要

•Jagged-1/Notch-1 is activated in experimental autoimmune encephalomyelitis (EAE).•Clemastine enhanced MBP and Oligo2 in corpus collasum.•Clemastine relieved EAE by activating F3/Contactin-1/Notch-1.•EAE motor behaviors were alleviated by Clemastine administration.

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关键词

Clemastine,Experimental autoimmune encephalomyelitis,Canonical/non-canonical pathway,F3/Contactin/Notch,Multiple sclerosis

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