Risk scores for major bleeding from direct oral anticoagulants: comparing predictive performance in patients with atrial fibrillation

•Direct oral anticoagulants (DOACs) are safer than warfarin, but concerns about bleeding persist.•Comparative performance of 6 scores in predicting major bleeding from DOACs was assessed.•Outcomes Registry for Better Informed Treatment of Atrial Fibrilation [ORBIT-AF] and Anticoagulation and Risk Factors in Atrial Fibrillation [ATRIA] showed the highest C-statistics in the initial 1100 days of DOAC treatment.•Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF] and Anticoagulation and Risk Factors in Atrial Fibrillation [ATRIA] outperformed 4 other risk scores in identifying major bleeding from DOACs.