Transperineal Versus Transrectal Magnetic Resonance Imaging–targeted and Systematic Prostate Biopsy to Prevent Infectious Complications: The PREVENT Randomized Trial

There is no significant difference between transperineal and transrectal biopsy infection rates without and with targeted antibiotic prophylaxis, respectively. The cancer detection rates were similar. Transperineal biopsy was associated with slightly more pain, but it improves antibiotic stewardship.